Reaction of 3,3-Dichloro-2-dichloroacetylaminoacrylonitrile with Amines |
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Authors: | Pil'o S. G. Brovarets V. S. Romanenko E. A. Drach B. S. |
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Affiliation: | (1) Institute of Bioorganic and Petroleum Chemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine |
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Abstract: | Polychlorinated enamidonitrile Cl2CÍC(CN)NHCOCHCl2 readily reacts with primary aromatic amines, dialkylamines, piperidine, and morpholine. The reaction is accompanied by complete elimination of chlorine atoms as chloride ions with formation of 4-cyanooxazoles having the corresponding amine residue in position 5 of the ring and a CHÍN or diaminomethyl moiety in position 2. The structure of 5-arylamino(dialkylamino)-4-cyano-2-formyloxazoles was confirmed by their acid hydrolysis, as well as by the condensation with phenylhydrazine, N-alkylrhodanines, and ethyl acetoacetate in the presence of urea. |
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