Synthesis and transformations of 3-acetylpyridine-2(1H)-thiones |
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Authors: | V. K. Zav’yalova A. A. Zubarev V. P. Litvinov |
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Affiliation: | (1) N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky prosp., 119991 Moscow, Russian Federation |
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Abstract: | Reactions of substituted 3-cyanopyridine-2(1H)-thiones with methyllithium gave 3-acetylpyridine-2(1H)-thiones. The best results were achieved by adding a solid-state thione to a solution of methyllithium in ether (thione: MeLi = 1: 3). The compounds obtained and their 3-pentanoyl analogs were used to synthesize a number of fused heterocyclic systems. Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 7, pp. 1504–1507, July, 2008. |
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Keywords: | 3-cyanopyridine-2(1H)-thiones 3-acetylpyridine-2(1H)-thiones 3-pentanoylpyridine-2(1H)-thiones methyllithium thieno[2,3-b]pyridines 3-cyanopyrido[2,3-b]thiopyrans 4,8-dialkyl-2-cyanomethylidenepyrido[2,3-b][1,3]thiazines |
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