| Hydroxylation of 3-nitrotyrosine by hydroxyl radical |
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| 作者姓名： | Jun Chen Dong Wei Qun Shi Yu Fen Zhao Yan Mei Li |
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| 作者单位： | Key Laboratory of Bioorganic Phosphorous Chemistry ＆ Chemical Biology （Ministry of Education）, Department of Chemistry, Tsinghua University, Beijing 100084, China |
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| 摘 要： | Hydroxylation of 3-nitrotyrosine (3-NT) and 3-NT containing peptide Gly-nitroTyr-Gly in aqueous solution by hydroxyl radical were investigated with gamma irradiation. The structures of the hydroxylated products were confirmed by electrospray ionization mass spectrometry and 1H NMR spectrometry. The reactivity of 3-nitrotyrosine has been investigated using density functional theory (DFT) calculation.
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| 关 键 词： | 3-硝基酪氨酸 羟基化作用 羟基 DFT |
| 收稿时间： | 2006-11-06 |
Hydroxylation of 3-nitrotyrosine by hydroxyl radical |
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| Jun Chen Dong Wei Qun Shi Yu Fen Zhao Yan Mei Li.Hydroxylation of 3-nitrotyrosine by hydroxyl radical[J].Chinese Chemical Letters,2007,18(5):542-544. |
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| Authors: | Jun Chen Dong Wei Qun Shi Yu Fen Zhao Yan Mei Li |
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| Institution: | Key Laboratory of Bioorganic Phosphorous Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China |
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| Abstract: | Hydroxylation of 3-nitrotyrosine (3-NT) and 3-NT containing peptide Gly-nitroTyr-Gly in aqueous solution by hydroxyl radical were investigated with gamma irradiation. The structures of the hydroxylated products were confirmed by electrospray ionization mass spectrometry and 1H NMR spectrometry. The reactivity of 3-nitrotyrosine has been investigated using density functional theory (DFT) calculation. |
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| Keywords: | 3-Nitrotyrosine Hydroxyl radical DFT Selective hydroxylation |
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