Simultaneous voltammetric detection of dopamine and uric acid in the presence of high concentration of ascorbic acid using multi-walled carbon nanotubes with methylene blue composite film-modified electrode |
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| Authors: | Suling Yang Gang Li Ran Yang Miaomiao Xia Lingbo Qu |
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| Institution: | (1) Department of Chemistry, Zhengzhou University, Zhengzhou, 450001, People’s Republic of China;(2) College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, 455002, People’s Republic of China;(3) Chemistry and Chemical Engineering School, Henan University of Technology, Zhengzhou, 450001, People’s Republic of China |
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| Abstract: | An electrochemically functional nanocomposite through the adsorption of methylene blue onto the multi-walled nanotubes (MB-MWNTs)
was prepared, and a sensitive voltammetric sensor was fabricated. The modified electrode showed excellent electrocatalytic
activity toward dopamine (DA) and uric acid (UA) in 0.1 M phosphate solution medium (pH 3.0). Compared to the bare electrode,
the MB-MWNTs film-modified electrode not only remarkably enhanced the anodic peak currents of DA and UA, i.e., shifted the
anodic peak potential of DA negatively, but also avoided the overlapping of the anodic peaks of DA and UA. The interference
of ascorbic acid (AA) was eliminated. Under the optimized conditions, the peak separation between AA and DA and between DA
and UA was 219 and 174 mV, respectively. In the presence of 1.0 mM AA and 10.0 μM UA, the anodic peak current was linear to
the concentration of DA in the range of 0.4–10.0 μM with a detection limit of 0.2 μM DA. The anodic peak current of UA was
linear to the concentration in the range of 2.0–20.0 and 20.0–200.0 μM with a lowest detection limit of 1.0 μM in the presence
of 1.0 mM AA and 1.0 μM DA. |
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