Analysis of multi-class preservatives in leave-on and rinse-off cosmetics by matrix solid-phase dispersion |
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Authors: | Sanchez-Prado Lucia Alvarez-Rivera Gerardo Lamas J Pablo Lores Marta Garcia-Jares Carmen Llompart Maria |
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Institution: | (1) Departamento de Quimica Analitica, Nutricion y Bromatologia, Facultad de Quimica. Campus Sur, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain; |
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Abstract: | Matrix solid-phase extraction has been successfully applied for the determination of multi-class preservatives in a wide variety
of cosmetic samples including rinse-off and leave-on products. After extraction, derivatization with acetic anhydride, and
gas chromatography–mass spectrometry analysis were performed. Optimization studies were done on real non-spiked and spiked
leave-on and rinse-off cosmetic samples. The selection of the most suitable extraction conditions was made using statistical
tools such as ANOVA, as well as factorial experimental designs. The final optimized conditions were common for both groups
of cosmetics and included the dispersion of the sample with Florisil (1:4), and the elution of the MSPD column with 5 mL of
hexane/acetone (1:1). After derivatization, the extract was analyzed without any further clean-up or concentration step. Accuracy,
precision, linearity and detection limits were evaluated to assess the performance of the proposed method. The recovery studies
on leave-on and rinse-off cosmetics gave satisfactory values (>78% for all analytes in all the samples) with an average relative
standard deviation value of 4.2%. The quantification limits were well below those set by the international cosmetic regulations,
making this multi-component analytical method suitable for routine control. The analysis of a broad range of cosmetics including
body milk, moisturizing creams, anti-stretch marks creams, hand creams, deodorant, shampoos, liquid soaps, makeup, sun milk,
hand soaps, among others, demonstrated the high use of most of the target preservatives, especially butylated hydroxytoluene,
methylparaben, propylparaben, and butylparaben. |
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