PHOTOMIMETIC EFFECT OF SEROTONIN ON YEAST CELLS IRRADIATED BY FAR-UV RADIATION |
| |
| Authors: | G Y Fraikin Marina G Strakhovskaya Leonid B Rubin |
| |
| Institution: | Biology Department, Moscow State University, Moscow 117234, USSR;*Physics Department, Moscow State University, Moscow 117234, USSR |
| |
| Abstract: | Abstract— The effect of serotonin on the survival of far-UV irradiated cells of the yeast Candida guillier-mondii was studied. Serotonin was found to have a photomimetic property. Preincubation of cells with serotonin results in protection against far-UV inactivation, whereas the post-radiation treatment with serotonin causes a potentiation of far-UV lethality. Both effects are similar to those produced by near-UV (334 nm) radiation. The observations provide support to the idea advanced by us previously that photosynthesized serotonin is the underlying cause of the two effects of near-UV radiation, photo-protection and potentiation of far-UV lethality. Experiments with an excision-deficient strain of the yeast Saccharomyces cerevisiae suggest that the effect of serotonin is by its binding to DNA. |
| |
| Keywords: | |
|
|
