5-Alpha- and 5-beta-2-deoxyintegristerone A,a 5-alpha and 5-beta isomer pair of ecdysteroids isolated from the Silene genus |
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| Authors: | Báthori M Kalász H Pongrácz Z Máthé I Kálmán A Argay G |
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| Institution: | Department of Pharmacognosy, University of Szeged, 6701 Szeged, E?tv?s utca 6, PO Box 121, Hungary. |
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| Abstract: | 5-Alpha-2-deoxyintegristerone A and 5-beta-2-deoxyintegristerone A were isolated from the aerial parts of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman using a specific combination of absorption column chromatography, preparative thin-layer chromatography and preparative HPLC. Both normal-phase and reversed-phase modes of HPLC were employed for isolation. Structural elucidation of 5-alpha-2-deoxyintegristerone A was completed by X-ray diffraction. Both 5-alpha-2-deoxyintegristerone A and 5-beta-2-deoxyintegristerone A were firstly isolated from this plant. We propose that 5-alpha-2-deoxyintegristerone A is not an artifact but an integral part of the ecdysteroid spectrum of Silene italica ssp. nemoralis (Waldst. and Kit.) Nyman. |
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