PREVENTION OF UV IRRADIATION INDUCED SUPPRESSION OF MONOCYTE FUNCTIONS BY RETINOIDS AND CAROTENOIDS in vitro |
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| Authors: | David J Schoen† Ronald R Watson |
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| Institution: | Department of Family and Community Medicine, Arizona Health Sciences Center, University of Arizona, Tucson, AZ 85724, USA |
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| Abstract: | Abstract— The effects of stimulation of human peripheral blood monocytes in vitro with retinoids and carotenoids, and subsequent exposure to ultraviolet light of the B wavelength were measured. The compounds were applied to the monocytes in culture for 24 h, and the washed cells were then exposed to UVB light up to 220 J/m2. The compounds tested protected the monocyte from UVB induced damage to phagocytic activity. This protection may be due to the antioxidant or UVB energy-quenching properties of these compounds. Monocyte cytotoxicity against a melanoma cell line was stimulated by exposure to the retinoids or carotenoids, but a protective effect in vitro against UVB damage was not seen for this cell function. |
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