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4-hydroxy-2-quinolones. 110. Bromination of 1-r-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides
Authors:I V Ukrainets  A A Tkach  L V Sidorenko  O V Gorokhova
Institution:(1) National Pharmaceutical University, Kharkiv, 61002, Ukraine
Abstract:1-R-4-Hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acid anilides have been prepared. It has been shown experimentally that these compounds are brominated by molecular bromine in glacial acetic acid at position 4 of the anilide fragment. The antitubercular properties of the compounds synthesized are discussed. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 10, pp. 1508–1516, October, 2006.
Keywords:4-hydroxy-2-oxo-1  2-dihydroquinoline-3-carboxylic acid amides  bromination  X-ray analysis  antitubercular activity
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