Stereoselective synthesis of (+)-boronolide |
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Authors: | Carda Miguel Rodríguez Santiago Segovia Beatriz Marco J Alberto |
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Institution: | U. P. de Química Inorgánica y Orgánica, Universidad Jaume I, E-12080 Castellón, Spain. |
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Abstract: | The delta-lactone boronolide (+)-1, a pharmacologically active, naturally occurring product, has been synthesized in enantiopure form with L-erythrulose as the chiral starting material. The key steps of the synthesis were a highly stereoselective aldol-reduction one-pot sequence, an indium-mediated diastereoselective aldehyde allylation, and a ring-closing metathesis. |
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