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Preparation and mechanical behavior of PLGA/nano-BCP composite scaffolds during in-vitro degradation for bone tissue engineering |
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| Authors: | M Ebrahimian-Hosseinabadi F AshrafizadehM Etemadifar Subbu S Venkatraman |
| Institution: | a Department of Materials Engineering, Isfahan University of Technology, Isfahan 84156-83111, Iran b Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran c Orthopedic Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan 81746-73461, Iran d Materials Science and Engineering School, Nanyang Technological University, 637819 Singapore |
| Abstract: | In this paper, the yield strength and elastic modulus of Poly (lactide-co-glycolide) (PLGA) and PLGA/nano-biphasic calcium phosphate (nBCP) composite scaffolds, before and during in-vitro degradation, have been evaluated. Composite scaffolds were made by using PLGA matrix and 10-50 wt.% nBCP powder as the reinforcement material. All scaffolds, with more than 89% porosity, were fabricated by thermally-induced phase separation (TIPS). During in-vitro degradation (0-8 weeks), the PLGA/nBCP scaffolds showed both more weight loss and better mechanical properties as compared to neat PLGA scaffolds. The PLGA/nBCP scaffolds with 30 wt.% nBCP illustrated the highest value of yield strength among the composite scaffolds, before and after degradation, until 6 weeks. After 8 weeks, the yield strength values were very poor and close to each other. The values of elastic modulus for all samples were less than the half of their initial values after 6 weeks. However, after 8 weeks, the elastic moduli of all samples reduced to negligible values. |
| Keywords: | Nano composite scaffold(s) In-vitro degradation Mechanical properties Biphasic calcium phosphate |
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