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Influence of electron beam irradiation on physicochemical properties of poly(trimethylene carbonate) |
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| Authors: | Joanna JozwiakowskaRadoslaw A Wach Bozena RokitaPiotr Ulanski Sameer P NalawadeDirk W Grijpma Jan FeijenJanusz M Rosiak |
| Institution: | a Institute of Applied Radiation Chemistry, Technical University of Lodz, Wroblewskiego 15, 93-590 Lodz, Poland b Institute for Biomedical Technology (BMTI), Department of Polymer Chemistry and Biomaterials, Faculty of Science and Technology, University of Twente, P.O. Box 217, 7500 AE Enschede, The Netherlands c Department of Biomedical Engineering, University Medical Center Groningen, University of Groningen, P.O. Box 196, 9700 AD Groningen, The Netherlands |
| Abstract: | Electron beam (EB) irradiation of poly(trimethylene carbonate) (PTMC), an amorphous, biodegradable polymer used in the field of biomaterials, results in predominant cross-linking and finally in the formation of gel fraction, thus enabling modification of physicochemical properties of this material without significant changes in its chemical structure. PTMC films (Mw: 167-553 kg mol−1) were irradiated with different doses using an electron accelerator. Irradiation with a standard sterilization dose of 25 kGy caused neither significant changes in the chemical composition of the polymer nor significant deterioration of its mechanical properties. Changes in viscosity-, number-, weight-, and z-average molecular weights of PTMC for doses lower than the gelation dose (Dg) as well as gel-sol analysis and swelling tests for doses above Dg indicate domination of cross-linking over degradation. EB irradiation can be considered as an effective tool for increasing the average molecular weight of PTMC and sterilization of PTMC-based biomaterials. |
| Keywords: | Degradation Crosslinking Electron beam irradiation Molecular weight changes Poly(trimethylene carbonate) |
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