One-pot Pd-catalyzed hydrostannation/Stille reaction with acid chlorides as the electrophiles |
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| Authors: | Kyoungsoo Lee |
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| Affiliation: | Department of Chemistry, Michigan State University, 540 Chemistry, East Lansing, MI 48824, USA |
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| Abstract: | A one-pot hydrostannation/Stille coupling sequence amenable to the employment of acid chloride electrophiles has been developed. In this protocol, palladium mediated alkyne hydrostannations using Me3SnF/PMHS as an in situ trimethyltin hydride source are followed by the addition of the acid chloride to afford a variety of α,β-unsaturated ketones in a single pot. |
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| Keywords: | Hydrostannation Stille reaction Polymethylhydrosiloxane Tin Acid chloride Enone synthesis |
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