Cyclization reaction of n-propargyl epoxyamide to acetylenic 2-azetidinone,a precursor to thienamycin and related carbapenems |
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| Authors: | Hiroshi Maruyama Masao Shiozaki Sadao Oida Tetsuo Hiraoka |
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| Institution: | 1. Process Development Laboratories, Sankyo Co., Ltd., Hiromachi, Shinagawaku, Tokyo, 140, Japan |
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| Abstract: | Base treatment of N-propargyl epoxyamide 5 afforded the acetylenic 3-(hydroxyethyl)-2-azetidinone 9a, which was subsequently transformed to phenyl thiolester 2, a versatile intermediate for the carbapenem synthesis. |
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