A highly stereoselective synthesis of (±)-dihydrofumariline-1 |
| |
| Authors: | Miyoji Hanaoka Masashi Iwasaki Chisato Mukai |
| |
| Institution: | Faculty of Pharmaceutical Sciences, Kanazawa University Takara-machi, Kanazawa 920, Japan |
| |
| Abstract: | Stereoselective sodium borohydride reduction of the 8,14-cycloberbine (9) derived from the protoberberine (7), followed by reductive cleavage of C8-N bond of the resulting 13-hydroxy-8, 14-cycloberbine (10) with sodium cyanoborohydride afforded the spirobenzylisoquinoline (12), N-methylation of which via the oxazolidine (13) provided (±)-dihydrofumariline-l (1). |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
