3-Bromo-2-(tert-butylsulfonyl)-1-propene. A multi-coupling reagent Part 1. |
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Authors: | P Knochel JF Normant |
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Institution: | Laboratoire de Chimie des Organo-éléments, tour 44-45 4 place Jussieu 75230 Paris Cédex 05 France |
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Abstract: | 3-Bromo-2-(tert-butylsulfonyl)-1-propene is easily available in two steps from allyl-tert-butylthioether (70% overall yield). It reacts with a great variety of carbanions to give functionnalized α, β-unsaturated sulfones of type in high yields. A second nucleophile (lithium cuprates) can then be added to compounds to furnish functionnalized sulfones of type (Y=SO2-tert-butyl). |
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