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Synthetic study of 1-substituted carbapenem antibiotics |
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| Authors: | Tomoyuki Shibata Kimio Iino Teruo Tanaka Toshihiko Hashimoto Yukiko Kameyama Yukio Sugimura |
| Affiliation: | Chemical Research Laboratories, Sankyo Co., Ltd., Hiromachi, Shinagawa-ku, Tokyo, 140, Japan |
| Abstract: | Total synthesis of 1-substituted carbapenems is described. The key step is the reaction of acetoxyazetidinone () with ketene silyl acetal (). |
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