Stereochemically controlled synthesis of unsaturated acids diphenylphosphinoyl (Ph2PO) -ketoacids |
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Authors: | Daniel Levin Stuart Warren |
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Affiliation: | University Chemical Laboratory, Lensfield Road, Cambridge CB2 1EW. U.S.A. |
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Abstract: | Acylation of phosphine oxide anions with derivatives of cyclic anhydrides or oxidative cleavage of cyclic allyl phosphine oxides gives Ph2PO-ketoacids: reduction, separation of diastereoisomers, and completion of the Horner-Wittig reaction gives single isomers () or () of unsaturated acids. |
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