A highly effective asymmetric synthesis of α-hydroxy acids by alkylation of chiral <span class="math"><math><mtext>n</mtext></math></span>-(benzyloxyacetyl)-<span class="math"><math><mtext>trans</mtext></math></span>-2,5-bis(methoxymethoxymethyl)pyrrolidine期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

按检索

A highly effective asymmetric synthesis of α-hydroxy acids by alkylation of chiral $n$ -(benzyloxyacetyl)- $trans$ -2,5-bis(methoxymethoxymethyl)pyrrolidine

Authors:	Masayuki Enomoto Yoshio Ito Tsutomu Katsuki Masaru Yamaguchi

Institution:	Department of Chemistry, Kyushu University 33, Hakozaki, Higashi-ku, Fukuoka 812, Japan

Abstract:	Alkylation of lithiated $N$ -(benzyloxyacetyl)- $trans$ -2,5-bis(mehtoxyymethoxymethyl)- pyrrolidine proceeded with high stereoselectivity (≥96% de) and subsequent transformations of the alkylated products gave synthetically useful α-benzyloxy acids or α-hydroxy acids of high enantiomeric purity.

Keywords:
本文献已被 ScienceDirect 等数据库收录！