General approach for the synthesis of polyquinenes the weiss reaction. Preparation of the chiral tetracyclo [6.6.0.01,5.08,12]tetradecane-3,6,10,13,-tetraene |
| |
Authors: | M Venkatachalam M Jawdosiuk M Deshpande JM Cook |
| |
Institution: | Department of Chemistry, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53201 U.S.A. |
| |
Abstract: | The aldol approach to construct the tetracyclic polyquinane skeleton of , followed by hydroboration and the HMPA mediated dehydration of four hydroxyl groups has resulted in the facile synthesis of the chiral polyquinene, tetracyclo6.6.0.01,5.08,12]-tetradecane-3,6,10,13-tetraene . This method completely avoids the troublesome fragmentation reactions earlier encountered when the strained tetraone was reacted with nucleophilic reagents. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|