Studies on the biosynthesis of terrecyclic acid A II confirmation of the cyclization mechanism and hydrogen shifts using [2-2H3]acetate and [213C2H3]acetate期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Studies on the biosynthesis of terrecyclic acid A II confirmation of the cyclization mechanism and hydrogen shifts using [2-²H₃]acetate and [2¹³C²H₃]acetate

Authors:	Akira Hirota Masahira Nakagawa Heiichi Sakai Akira Isogai Kazuo Furihata Haruo Seto

Affiliation:	Department of Agricultural Chemistry, University of Osaka Prefecture, Sakai, Osaka 591, Japan;Department of Agricultural Chemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan;Institute of Applied Microbiology, The University of Tokyo, Bunkyo-ku, Tokyo 113, Japan

Abstract:	Feeding experiments with [2-³H₃]acetate and [2-¹³C²H₃]acetate in $Aspergillus terreus$ Thom No. 14 indicated that the hydrogen at C-2 in terrecyclic acid A is incorporated without migration from the precursor acetic acid; the results favour our group's earlier speculation for the cyclization to the tricyclic skeleton in the biosynthetic scheme.

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