| 荷移络合物分光光度法测定头孢噻肟钠的研究 |
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| 引用本文： | 宋健玲,谢鲜梅.荷移络合物分光光度法测定头孢噻肟钠的研究[J].光谱实验室,2011,28(1):352-356. |
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| 作者姓名： | 宋健玲 谢鲜梅 |
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| 作者单位： | 太原理工大学化学化工学院,太原市迎泽西大街79号,030024 |
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| 摘 要： | 研究了头孢噻肟钠与对苯醌(p-BQ)的荷移反应.确定了形成电荷转移络合物的最佳反应条件.在硼砂介质中,电子给予体头孢噻肟钠与电子接受体对苯醌于室温下可形成1:2的荷移络合物,络合物的最大吸收波长为587.5nm;表观摩尔吸光系数ε=9.92×103L·mol-1·cm-1;线性范围为2-36μg/mL;对形成荷移络合物...
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| 关 键 词： | 荷移反应 分光光度法 头孢噻肟钠 对苯醌 |
Determination of Cefotaxime Sodium by Charge-Transfer Complex-Spectrophotometry |
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| SONG Jian-Ling,XIE Xian-Mei.Determination of Cefotaxime Sodium by Charge-Transfer Complex-Spectrophotometry[J].Chinese Journal of Spectroscopy Laboratory,2011,28(1):352-356. |
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| Authors: | SONG Jian-Ling XIE Xian-Mei |
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| Institution: | SONG Jian-Ling XIE Xian-Mei(College of Chemistry and Chemical Engineering,Taiyuan University of Technology,Taiyuan 030024,P.R.China) |
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| Abstract: | The charge transfer reaction between cefotaxime sodium and p-benzoquinone was studied by spectrophotometry.The optimal experimental conditions for the formation of charge transfer complex were confirmed.At room temperature,cefotaxime sodium reacted as electron donor with electron receiver p-benzoquinone in borax medium and to form a charge transfer complex with ratio of 1：2,and the apparent molar absorptivity coefficient was 9.92×103L.mol-1.cm-1 with the biggest absorption wavelengh at 587.5nm,and the range linearity of cefotaxime sodium obeyed Beer’s law in the range of 2—36μg/mL.The machaism of formation of charge transfer complex was investigated.The method was applied for the determination of cefotaxime sodium of injection.The recoveries were 98.43%—100.4% and the relative standard deviation was less than or equal to 2.65%. |
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| Keywords: | Charge Transfer Reaction Spectrophotometry Cefotaxime Sodium p-Benzoquinone |
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