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An Electrochemical Way to Generate Amphiphiles from Hydrazones for the Synthesis of 1,2,4-Triazole Scaffold Cyclic Compounds |
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| Authors: | Wangyu Li Mingteng Xiong Xiao Liang Dungai Wang Heping Zhu Prof?Dr Yuanjiang Pan |
| Institution: | 1. Department of Chemistry, Zhejiang University, Hangzhou, 310027 China
These authors contributed equally.;2. Department of Chemistry, Zhejiang University, Hangzhou, 310027 China Zhejiang Yangshengtang Natural Medicine Institute, Hangzhou, 310027 China;3. Department of Chemistry, Zhejiang University, Hangzhou, 310027 China |
| Abstract: | An electro-oxidative cyclization pathway in which hydrazones are selected as starting materials to generate amphiphiles by reacting with benzylamines and benzamides was reported. This strategy successfully prepared a series of 1,2,4-triazoles in satisfactory yields. Moreover, the use of cheap stainless steel as the anode, the feasibility to conduct the transformation as a one-pot reaction and the proof that scaling-up these reactions is possible make this transformation attractive for potential application in industry. |
| Keywords: | amphiphiles cyclization electrooxidation one-pot reaction 1 2 4-trizaole |