Phthalide metabolites produced by mangrove endophytic fungus Pestalotiopsis sp. SAS4 |
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| Authors: | Jiayin Peng Peiwen Chen Chuwen Li Juntao Liu Yijun Sun Mingze Yang Bo Ding Hongbo Huang Yiwen Tao |
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| Institution: | Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, China |
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| Abstract: | Two new phthalide derivatives ( 1 – 2 ) and four known phthalide compounds ( 3 – 6 ) were purified from the culture of a mangrove endophytic fungus Pestalotiopsis sp. SAS4. Their chemical structures were established by analyses of 1D and 2D nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HR-MS) spectroscopic data. All of these compounds were evaluated in vitro for antibacterial, cytotoxicity, and resistance to hypoxic–ischemic injury activities. |
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