Tri-functional unit groups contained polyurethane composites with excellent antibacterial property and biocompatibility |
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| Authors: | Chuyao Wang Yunyun Xue Hua Tian Zihao Zhao Shuyang Shen Lifeng Fang Ronglu Cui Jun Han Baoku Zhu |
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| Institution: | Key Laboratory of Macromolecular Synthesis and Functionalization (Ministry of Education), ERC of Membrane and Water Treatment (Ministry of Education), Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China |
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| Abstract: | As biomaterials, it is essential for polyurethane (PU) to have excellent antibacterial activity and biocompatibility at the same time. Herein, quaternary ammonium groups, sulfonic groups, and alkyl groups simultaneously introduced hyperbranched poly(amidoamine) (HPA-QSA) was synthesized, which was further used to blend with PU and prepared as films. HPA-QSA/PU blend films showed strong antibacterial activity to kill more than 99.99% of both Gram-positive and Gram-negative bacteria due to the quaternary ammonium groups and long alkyl groups, as well as good biocompatibility through protein-resistance, cytotoxicity, hemolysis assays under the combined action of cations and anions. Moreover, they exhibited stable antibacterial activity and low cytotoxicity in aquatic solutions. Overall, HPA-QSA/PU films prepared by facile blending process exhibit great promise as low-cost, effective antibacterial, good biocompatible materials, indicating an appealing prospect in biomedical fields. |
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| Keywords: | antibacterial biocompatible hyperbranched polyurethane |
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