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Monodispersed polymer particles with tunable surface structures: Droplet microfluidic-assisted fabrication and biomedical applications |
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| Authors: | Xi Mao Mian Wang Shaohong Jin Jingyi Rao Renhua Deng Jintao Zhu |
| Institution: | 1. State Key Laboratory of Materials Processing and Die & Mould Technology, Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, China
Contribution: Conceptualization (supporting), Writing - original draft (lead);2. State Key Laboratory of Materials Processing and Die & Mould Technology, Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, China Contribution: Writing - original draft (supporting), Writing - review & editing (supporting);3. State Key Laboratory of Materials Processing and Die & Mould Technology, Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, China Contribution: Writing - review & editing (supporting);4. State Key Laboratory of Materials Processing and Die & Mould Technology, Key Laboratory of Materials Chemistry for Energy Conversion and Storage of Ministry of Education, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology (HUST), Wuhan, China |
| Abstract: | Polymer particles are key materials in various biomedical applications, including drug delivery, cellular immunity, cell capture, biochip, etc. Droplets produced by microfluidics have been widely applied as templates for the fabrication of polymer particles with controllable sizes and narrow size distributions. Compared to smooth polymer particles, those with surface microstructures (e.g., tentacles, bubbles, wrinkles and pits) are more attractive due to their increased surface area and biomimetic structural characteristics. In this review, we summarized representative methods for the preparation of monodispersed polymer particles with various surface microstructures based on droplet microfluidics, as well as their typical bioapplications in drug delivery, cellular immunity and cell capture. Finally, the current challenges and further development in this research area are discussed. |
| Keywords: | bionic microorganisms droplet microfluidics polymer particles porous particles surface microstructures |