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Mechanistic modeling and simulation of a complex low and high loading elution behavior of a polypeptide in cation exchange chromatography |
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| Authors: | Jonas Koch Daniel Scheps Matthias Gunne Oliver Boscheinen Mathias Hafner Christian Frech |
| Institution: | 1. Institute for Biochemistry, University of Applied Sciences, Mannheim, Germany;2. CMC Microbial Platform, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany;3. IA MSAT M&I DS, Sanofi-Aventis Deutschland GmbH, Frankfurt am Main, Germany;4. Institute of Molecular Biology and Cell Culture Technology, University of Applied Sciences, Mannheim, Germany |
| Abstract: | |
| Keywords: | cation exchange chromatography mechanistic modeling polypeptide preparative chromatography self-association isotherm |