Coupling Effect of Ion Channel Clusters on Calcium Signalling |
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Authors: | TANG Jun JIA Ya YI Ming MA Jun YU Guang |
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Affiliation: | Department of Physics and Institute of Biophysics, Huazhong Normal University, Wuhan 430079College of Science, China University of Mining and technology, Xuzhou 221008 |
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Abstract: | Based on a modified intracellular Ca2+ model involving diffusive coupling of two calcium ion channel clusters, the effects of coupling on calcium signalling are numerically investigated. The simulation results indicate that the diffusive coupling of clusters together with internal noise determine the calcium dynamics of single cluster, and for either homogeneous or heterogeneous coupled clusters, the synchronization of clusters, which is important to calcium signalling, is enhanced by the coupling effect. |
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Keywords: | 87.16.Ac 02.60.Cb 05.40.-a |
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