The Baylis-Hillman approach to quinoline derivatives |
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| Authors: | Familoni Oluwole B Klaas Phindile J Lobb Kevin A Pakade Vusumzi E Kaye Perry T |
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| Affiliation: | Department of Chemistry, Rhodes University, Grahamstown, 6140, South Africa. |
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| Abstract: | Baylis-Hillman reactions of 2-nitrobenzaldehydes with various activated alkenes afford adducts that undergo reductive cyclisation to quinoline derivatives. The chemo- and regioselectivity of cyclisation appears to be influenced by the choice of both the substrate and the reagent system, and competing reactions have been observed. |
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