Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines |
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Authors: | Jabeen Ishrat Wetwitayaklung Penpun Klepsch Freya Parveen Zahida Chiba Peter Ecker Gerhard F |
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Institution: | Department of Medicinal Chemistry, University of Vienna, Vienna, Austria. |
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Abstract: | A series of enantiomerically pure benzopyrano3,4-b]1,4]oxazines have been synthesised and tested for their ability to inhibit P-glycoprotein. Reducing the conformational flexibility of the molecules leads to remarkable differences in the activity of diastereoisomers. Docking studies into a homology model of human P-gp provide first insights into potential binding areas for these compounds. |
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