An investigation into the origin of the dramatically reduced reactivity of peptide-prolyl-thioesters in native chemical ligation |
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| Authors: | Pollock Samuel B Kent Stephen B H |
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| Affiliation: | Department of Chemistry, Institute for Biophysical Dynamics, The University of Chicago, Chicago, Illinois 60637, USA. |
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| Abstract: | The low reactivity of peptide-prolyl-thioesters in native chemical ligation is not due to steric effects at the β-carbon, but rather to the presence of a carbonyl moiety on the nitrogen atom of the proline. |
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