Evidence for a trianion intermediate in the metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid. Methodology and application to racemic 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives |
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| Authors: | Le Tin Thanh Chau Nguyet Trang Thanh Nguyen Tai Tan Brien Josselin Thai Trieu Tien Nourry Arnaud Castanet Anne-Sophie Nguyen Kim Phi Phung Mortier Jacques |
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| Institution: | Universite? du Maine and CNRS, Unite? de Chimie Organique Mole?culaire et Macromole?culaire (UMR 6011), Faculte? des Sciences, avenue Olivier Messiaen, 72085 Le Mans Cedex 9, France. |
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| Abstract: | The metalation of 4-hydroxy-6,7-dimethoxy-8-methyl-2-naphthoic acid (8) affording trianion 6 is presented and applied to the regioselective efficient construction of a series of 5,5'-didesisopropyl-5,5'-dialkylapogossypol derivatives 3 that are potent pan-active inhibitors of antiapoptotic Bcl-2 family proteins. |
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