Modular 'click' sensors for zinc and their application in vivo |
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Authors: | Jobe Kajally Brennan Caroline H Motevalli Majid Goldup Stephen M Watkinson Michael |
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Affiliation: | School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK. |
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Abstract: | Although the central role that zinc plays in many biological processes and important disease states is now well-established, there remains a pressing need to develop an absolute understanding of the underlying biology of zinc trafficking in terms of its dynamic and quantitative processing in specific organelles. Here we describe the modular synthesis of zinc sensors using a 'click' approach and demonstrate the applicability of our new sensors in vivo using a zebrafish model. |
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