Przewalskin A: A new C23 terpenoid with a 6/6/7 carbon ring skeleton from Salvia przewalskii maxim |
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| Authors: | Xu Gang Hou Ai-Jun Wang Rui-Rui Liang Guang-Yu Zheng Yong-Tang Liu Ze-Yuan Li Xiao-Li Zhao Yu Huang Sheng-Xiong Peng Li-Yan Zhao Qin-Shi |
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| Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, PRC. |
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| Abstract: | Przewalskin A (1), a novel C23 terpenoid with a 6/6/7 carbon ring skeleton, was isolated from Salvia przewalskii. Its structure was determined by comprehensive 1D NMR, 2D NMR, and MS spectroscopic analysis and subsequently confirmed by a single-crystal X-ray diffraction study of its PDC oxidation derivative (2). Compounds 1 and 2 showed modest anti-HIV-1 activity with EC50 = 41 and 89 microg/mL, respectively. |
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