Artificial nucleosides possessing metal binding sites at the 3'- and 5'-positions of the deoxyribose moieties |
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Authors: | Chiba Jun-Ya Tanaka Kentaro Ohshiro Yukinori Miyake Ryosuke Hiraoka Shuichi Shiro Motoo Shionoya Mitsuhiko |
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Affiliation: | Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Japan. |
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Abstract: | This paper describes a convenient synthetic procedure for nucleoside mimics, 1-6, in which the 3',5'-hydroxy groups of natural 2'-deoxythymidine or 2'-deoxyadenosine are replaced by thiol, amine, or alkylthiol groups. Such nucleosides would be built up into a single DNA strand with cooperative participation of metal coordination, where internucleoside linkages are replaced by metal complexation motifs. The X-ray crystal structure and complexation behaviors of 3',5'-dithiothymidine, 1, with Au(I) are also reported. |
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