Topoisomerase Inhibition,Nucleolytic and Electrolytic Contribution on DNA Binding Activity Exerted by Biological Active Analogue of Coordination Compounds |
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Authors: | Mohan N Patel Bhupesh S Bhatt Promise A Dosi |
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Institution: | (1) Department of Chemistry, Sardar Patel University, Vallabh Vidyanagar, 388 120, Gujarat, India |
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Abstract: | The neutral mononuclear copper complexes with the quinolone antibacterial drug ciprofloxacin and bipyridine derivatives have
been synthesized and characterized. Complexes were screened for their antibacterial activity against three Gram(−) and two Gram(+) bacteria, and study suggests inhibition of gyrase activity by metal complexes as the possible mechanism. The nucleolytic
activity of adducts was carried out on double stranded pUC19 DNA using gel electrophoresis in the presence of radical scavenging
agents that suggest hydrolytic cleavage mechanism for plasmid DNA. |
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