Unexpected formation of tetrasubstituted 2,3-dihydrofurans from the reactions of beta-keto polyfluoroalkanesulfones with aldehydes |
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| Authors: | Xing Chunhui Zhu Shizheng |
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| Institution: | Key Laboratory of Organofluorine Chemistry, Shanghai Institution of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin lu, Shanghai 200032, PR China. |
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| Abstract: | Catalyzed by piperidine, the reactions of beta-keto polyfluoroalkanesulfones with aromatic aldehydes afforded the unexpected tetrasubstituted 2,3-dihydrofurans in good yields, probably proceeding through the normal Knoevenagel condensation products. This reaction provided an efficient and novel method for the stereoselective synthesis of fluorine-containing tetrasubstituted trans-2,3-dihydrofurans. |
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