Synthesis of glyco(lipo)peptides by liposome-mediated native chemical ligation |
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Authors: | Ingale Sampat Buskas Therese Boons Geert-Jan |
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Institution: | Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA. |
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Abstract: | Although native chemical ligation (NCL) is emerging as a powerful method for the assembly of (glyco)peptide building blocks, its applicability is reduced when peptide segments are poorly soluble in aqueous buffer. We have found that incorporating reactants in liposomes allows NCL of lipophilic peptides and lipopeptides. Furthermore, the reaction rates of liposome-mediated NCL are higher than traditional reaction conditions resulting in improved yields. reaction: see text] |
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