Rapid deprotection of <Emphasis Type="BoldItalic">N</Emphasis>-Boc amines by TFA combined with freebase generation using basic ion-exchange resins

Summary The deprotection of N-Boc amines was rapidly accomplished using 5 equivalents of TFA in methylene chloride in a focused microwave instrument with irradiation at 60 ^∘C for 30 min. The freebase amines are then obtained by scavenging the crude reaction mixture with the basic Amberlyst A-21 ion-exchange resin. This procedure is suitable for the parallel deprotection of N-Boc amines.