Synthesis of functional derivatives of the [3,3′-Co(1,2-C2B9H11)2] anion |
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| Authors: | Igor B Sivaev Zoya A StarikovaStefan Sjöberg Vladimir I Bregadze |
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| Institution: | a A.N. Nesmeyanov Institute of Organo-Element Compounds, Russian Academy of Sciences, Vavilov Str. 28, 117813 Moscow, Russia
b Department of Organic Chemistry, Institute of Chemistry, Uppsala University, P.O. Box 531, S-75121 Uppsala, Sweden |
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| Abstract: | A series of various functional derivatives of the cobalt bis(1,2-dicarbollide) anion 8-XCH2CH2OCH2CH2O-3,3′-Co(1,2-C2B9H10)(1′,2′-C2B9H11)]− (X=OH, NH2, and CH(NH2)COOH) were prepared by the ring-opening reactions of 8-O(CH2CH2)2O-3,3′-Co(1,2-C2B9H10)(1′,2′-C2B9H11)] with different nucleophiles followed by functional group interconversion reactions. Acidic hydrolysis of 8-NCCH2CH2OCH2CH2O-3,3′-Co(1,2-C2B9H10)(1′,2′-C2B9H11)]− resulted in the shorter-chain alcohol 8-HOCH2CH2O-3,3′-Co(1,2-C2B9H10)(1′,2′-C2B9H11)]−. Structures of (Bu4N)8-AcNHC(COOEt)2CH2CH2OCH2CH2O-3,3′-Co(1,2-C2B9H10)(1′,2′-C2B9H11)] and 8-(1-C5H5N)CH2CH2OCH2CH2O-3,3′-Co(1,2-C2B9H10)(1′,2′-C2B9H11)] were determined by the single crystal X-ray diffraction method. Perspectives of application of functionalized cobalt bis(1,2-dicarbolide) derivatives in nuclear medicine are discussed. |
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| Keywords: | Cobalt bis(dicarbollide) Functional derivatives Crystal structures Nuclear medicine Boron neutron capture therapy |
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