| 2＇，3＇－O－异亚丙基－5＇－O－［N，N－二（2－氯乙基）磷酰胺基］核苷的合成 |
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| 引用本文： | 陈茹玉,迟国臣,陈小茹.2＇，3＇－O－异亚丙基－5＇－O－［N，N－二（2－氯乙基）磷酰胺基］核苷的合成[J].高等学校化学学报,1996(3). |
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| 作者姓名： | 陈茹玉 迟国臣 陈小茹 |
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| 作者单位： | 南开大学元素有机化学研究所 |
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| 摘 要： | ２＇，３＇－Ｏ－异亚丙基－５＇－Ｏ－［Ｎ，Ｎ－二（２－氯乙基）磷酰胺基］核苷的合成陈茹玉，迟国臣，陈小茹（南开大学元素有机化学研究所，天津，３０００７１）关键词核苷，亚磷酰化，抗肿瘤活性很多核苷类化合物具有很好的抗肿瘤、抗病毒等生物活性，某些化合物已...
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| 关 键 词： | 核苷，亚磷酰化，抗肿瘤活性 |
Synthesis of 5'-O-(N, N-Bis(2-chloroethyl) phosphoramide)-2',3',-O-isopropylidenenucleosides |
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| CHEN Ru-Yu,CHI Guo-Chen,CHEN Xiao-Ru.Synthesis of 5''''-O-(N, N-Bis(2-chloroethyl) phosphoramide)-2'''',3'''',-O-isopropylidenenucleosides[J].Chemical Research In Chinese Universities,1996(3). |
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| Authors: | CHEN Ru-Yu CHI Guo-Chen CHEN Xiao-Ru |
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| Abstract: | A number of new title compounds were synthesized.The structures of all the products had been confirmed by elementary analysis,1H NMR and IR.The results of preliminary biological tests indicated that the title compounds had the inhibition effect against HL-60 cell lines and BCap cell lines. |
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| Keywords: | Nucleoside Phosphitylate Antitumor activity |
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