Relative and absolute stereochemistry of quinadoline B, an inhibitor of lipid droplet synthesis in macrophages |
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| Authors: | Koyama Nobuhiro Inoue Yusuke Sekine Masae Hayakawa Yoichi Homma Hiroshi Omura Satoshi Tomoda Hiroshi |
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| Institution: | School of Pharmacy, Kitasato University, Tokyo, Japan. |
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| Abstract: | New fungal metabolites, designated quinadolines A (1) and B (2), were isolated from culture broth of Aspergillus sp. FKI-1746, and their structures were elucidated by NMR spectroscopy. The complete relative and absolute stereochemistry of 2 was determined by X-ray crystallography and amino acid analysis using a chiral column. Quinadolines moderately inhibited lipid droplet synthesis in mouse macrophages. |
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