Spatial structure of dimeric guanolides. Crystal and molecular structure of the diguanolide handelin

The structure of the disesquiterpene lactone handelin, in the form of the solvate with dimethyl sulfoxide C₃₂H₄₀O₈·C₂H₆OS has been established by the x-ray structural method (diffractometer, CuK radiation, 1976 reflections, direct method, R=0.102). The results of the investigation confirm the structure of handelin proposed previously on the basis of spectral studies. A comparative analysis has been made of the conformations of the rings of handelin, chrysanthelide, absinthin, anabsin, and artelein with those observed in A/B-cis,B/C-trans-linked monoguaianolides.Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of Uzbekistan, Tashkent, Fax (3712) 62 73 48; and Tashkent Institute of Irrigation and the Mechanization of Agriculture. Translated from Khimiya Prirodnykh Soedinenii, No. 2, pp. 204–212, March–April, 1994.