"Tethered" Ru(II) catalysts for asymmetric transfer hydrogenation of ketones |
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Authors: | Cheung Fung Kei Kathy Hayes Aidan M Hannedouche Jerome Yim Aveline S Y Wills Martin |
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Institution: | Department of Chemistry, University of Warwick, Coventry, CV4 7AL, United Kingdom. |
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Abstract: | Stereochemically well-defined ruthenium(II) catalysts have been applied to the asymmetric transfer hydrogenation of a series of ketones. In one case, statistical experimental design was employed to optimize the enantiomeric excess of the product. In the case of the TsDPEN-based systems, the replacement of trans-1,2-diphenyl substitution with cis-, or deletion of one of the phenyl groups, results in significant deterioration of the enantiomeric excess. A new method is described for the synthesis of tethered amino alcohol-containing catalysts. |
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