FORMATION OF 5-HYDROXYMETHYLCYTOSINE-CONTAINING PYRIMIDINE DIMERS IN UV-IRRADIATED BACTERIOPHAGE T4 DNA |
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| Authors: | John D Childs Michael J Ellison† Raymond Pilon |
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| Institution: | Health Sciences Division, Atomic Energy of Canada Ltd, Chalk River, Ontario KOJ IJO, Canada |
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| Abstract: | Cyclobutyl pyrimidine dimers composed of 5-hydroxymethylcytosine and thymine (5HMC>T dimer for a mutant of T4 ( denV ) that is unable to excise pyrimidine dimers from its DNA. The ability of 5HMC to form dimers suggests that other modified pyrimidines such as 5-methylcytosine can participate in dimer formation, particularly at the UV wavelengths in sunlight likely to be responsible for the induction of skin cancer. |
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