Solvent generated liquid-liquid systems on unmodified silica

Summary The liquid-liquid distribution properties of three liquid-liquid systems, solvent generated on silicagel, were investigated by correlating retention volumes of solutes with their statically determined partition coefficients. The application of these phase systems for the prediction of partition coefficients from chromatographic data and the performance of solvent generated liquid-liquid columns were studied. The results show that liquid-liquid distribution is by far the dominating retention process for the investigated binary liquid-liquid systems. This allows the determination of liquid-liquid partition coefficients with an accuracy of about 5% from chromatographic data. Further the solvent generated liquid-liquid systems show a surprisingly good column performance with theoretical plate heights of 2 times the particle diameter at the minimum of the H/〈v〉 curve. Presented at the 15th International Symposium on Chromatography, Nürnberg, October 1984