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Stereoselective synthesis of hyptolide and 6-epi-hyptolide |
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| Authors: | Jorge Garcí a-Fortanet, Juan Murga, Miguel Carda,J.A. Marco, |
| Affiliation: | aDepart. de Q. Inorgánica y Orgánica, Univ. Jaume I, Castellón, E-12080 Castellón, Spain bDepart. de Q. Orgánica, Univ. de Valencia, E-46100 Burjassot, Valencia, Spain |
| Abstract: | The first stereoselective syntheses of the naturally occurring, ,β-unsaturated lactone hyptolide 1 and of its nonnatural epimer at C-6 are described. Ethyl l-lactate was the chiral starting material. Key steps of these syntheses were a Brown's asymmetric allylation, a Carreira's asymmetric ethynylation and a ring closing metathesis. |
| Keywords: | Hyptolide Ring-closing metathesis Asymmetric allylboration Asymmetric ethynylation Chiral pool |
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