Expression of Galpha14 in sweet-transducing taste cells of the posterior tongue |
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| Authors: | Marco Tizzano Gennady Dvoryanchikov Jennell K Barrows Soochong Kim Nirupa Chaudhari Thomas E Finger |
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| Institution: | (1) Rocky Mountain Taste & Smell Center, Univ. Colorado Denver Sch. Medicine, 80045 Aurora, CO, USA;(2) Dept. Cell & Devel. Biology, Univ. Colorado Denver Sch. Medicine, 80045 Aurora, CO, USA;(3) Department of Physiology and Biophysics, University of Miami Miller School of Medicine, 33136 Miami, FL, USA;(4) Department of Physiology, Temple University Medical School, 3420 N Broad St, 19140 Philadelphia, PA, USA;(5) Program in Neurosciences, University of Miami Miller School of Medicine, 33136 Miami, FL, USA |
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| Abstract: | Background "Type II"/Receptor cells express G protein-coupled receptors (GPCRs) for sweet, umami (T1Rs and mGluRs) or bitter (T2Rs),
as well as the proteins for downstream signalling cascades. Transduction downstream of T1Rs and T2Rs relies on G-protein and
PLCβ2-mediated release of stored Ca2+. Whereas Gαgus (gustducin) couples to the T2R (bitter) receptors, which Gα-subunit couples to the sweet (T1R2 + T1R3) receptor
is presently not known. We utilized RT-PCR, immunocytochemistry and single-cell gene expression profiling to examine the expression
of the Gαq family (q, 11, 14) in mouse taste buds. |
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