| THE SIMULATION AND OPTIMIZATION OF GRADIENT ELUTION HPLC |
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| 引用本文： | 林炳承,刘文烨,卢佩章,D.L.MASSART,M.DE.SMET,B.KOPPENHOEFER. THE SIMULATION AND OPTIMIZATION OF GRADIENT ELUTION HPLC[J]. 中国科学B辑(英文版), 1992, 0(9) |
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| 作者姓名： | 林炳承 刘文烨 卢佩章 D.L.MASSART M.DE.SMET B.KOPPENHOEFER |
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| 作者单位： | Dalian Institute of Chemical Physics，Academia Sinica，Dalian 116012PRC，Dalian Institute of Chemical Physics，Academia Sinica，Dalian 116012PRC，Dalian Institute of Chemical Physics，Academia Sinica，Dalian 116012PRC，Free University of Brussels，Belgium，Free University of Brussels，Belgium，University of Tuebingen，Germany |
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| 摘 要： | The movement of a particular component along an HPLC column is studied on the ba-sis of equilibrium equations. Numerical simulation of multi--step gradient elution HPLC isperformed by means o? a personal computer program. The location x, as a fraction of thecolumn length, for a given time t o? each compound is calculated, the velocity and corre-sponding acceleration are given as well. Diagrams for x,dx/dt and d~2x/dt~2 versus t display themovement process of the different components along the HPLC column during gradient elu-tion. The prediction of the retention time and peak width, and the optimization for the multi-step gradient elution HPLC are all based on such simulation and the molecular structure ofthe. components is separated as well.
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THE SIMULATION AND OPTIMIZATION OF GRADIENT ELUTION HPLC |
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| LIN BING-CHENG,LIU WEN-YE,LU PEI-ZHANG,D. L. MASSART,M. DE. SMET,B. KOPPENHOEFER Dalian Institute of Chemical Physics,Academia Sinica,Dalian ,PRC Free University of Brussels,Belgium University of Tuebingen,Germany. THE SIMULATION AND OPTIMIZATION OF GRADIENT ELUTION HPLC[J]. Science in China(Chemistry), 1992, 0(9) |
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| Authors: | LIN BING-CHENG LIU WEN-YE LU PEI-ZHANG D. L. MASSART M. DE. SMET B. KOPPENHOEFER Dalian Institute of Chemical Physics Academia Sinica Dalian PRC Free University of Brussels Belgium University of Tuebingen Germany |
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| Affiliation: | LIN BING-CHENG,LIU WEN-YE,LU PEI-ZHANG,D. L. MASSART,M. DE. SMET,B. KOPPENHOEFER Dalian Institute of Chemical Physics,Academia Sinica,Dalian 116012,PRC Free University of Brussels,Belgium University of Tuebingen,Germany |
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| Abstract: | The movement of a particular component along an HPLC column is studied on the ba-sis of equilibrium equations. Numerical simulation of multi--step gradient elution HPLC isperformed by means o? a personal computer program. The location x, as a fraction of thecolumn length, for a given time t o? each compound is calculated, the velocity and corre-sponding acceleration are given as well. Diagrams for x,dx/dt and d~2x/dt~2 versus t display themovement process of the different components along the HPLC column during gradient elu-tion. The prediction of the retention time and peak width, and the optimization for the multi-step gradient elution HPLC are all based on such simulation and the molecular structure ofthe. components is separated as well. |
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| Keywords: | HPLC multi-step gradient elution simulation in HPLC column optimization separation of chiral drugs |
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