| A Practical and Convenient Synthetic Process of 3-O-Decladinose-6-methyl 10,11-dehydrate-erythromycin-3-one-2'-acetate, an Important Intermediate of Ketolides Synthesis |
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| 作者姓名： | WEI Xin
YOU Qi-Dong |
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| 作者单位： | WEI,Xin（Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009）
YOU,Qi-Dong（Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009） |
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| 摘 要： | 3-O-Decladinose-6-methyl-10,11-dehydrate-erythromycin-3-one-2'-acetate (5) is an important intermediate for the synthesis of ketolides antibiotics.1] In the improved synthetic method of compound 5, the more common reagent PCC2]was used instead of the expensive reagent EDC and methanesulfonic anhydride.3～4] In this way, compound 5 was obtained efficiently and economically in five steps from clathromycin 1 without being further purfied by column chromatography.
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A Practical and Convenient Synthetic Process of 3-O-Decladinose-6-methyl 10,11-dehydrate-erythromycin-3-one-2'-acetate, an Important Intermediate of Ketolides Synthesis |
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| WEI,Xin,YOU,Qi-Dong.A Practical and Convenient Synthetic Process of 3-O-Decladinose-6-methyl 10,11-dehydrate-erythromycin-3-one-2''''-acetate, an Important Intermediate of Ketolides Synthesis[J].Chinese Journal of Organic Chemistry,2004,24(Z1):366. |
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| Authors: | WEI Xin YOU Qi-Dong |
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| Abstract: | 3-O-Decladinose-6-methyl-10,11-dehydrate-erythromycin-3-one-2'-acetate (5) is an important intermediate for the synthesis of ketolides antibiotics.1] In the improved synthetic method of compound 5, the more common reagent PCC2]was used instead of the expensive reagent EDC and methanesulfonic anhydride.3～4] In this way, compound 5 was obtained efficiently and economically in five steps from clathromycin 1 without being further purfied by column chromatography. |
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